Abstract Details
Abstract Title
Antifibrotic activity of silymarin/?-cyclodextrins in carbon tetrachloride-induced hepatotoxicity in mice
Abstract Text
Silymarin, a standardized extract of the milk thistle (Silybum marianum), has a long tradition as a herbal remedy, and was introduced as a hepatoprotective agent a few years ago. The aim of this study was to investigate the effects of sylimarin and its different cyclodextrin formulations (silymarin/randomly methylated ?-cyclodextrin and silymarin/hydroxylpropyl-?-cyclodextrin) on carbon tetrachloride (CCl4)- induced hepatic fibrosis. Swiss mice were treated with CCl4 dissolved in olive oil (20% v/v, 2 ml/kg) intraperitoneally (i.p.), twice a week for 4 weeks. Silymarin and formulations (100 mg/kg) was given orally to mice for the last two weeks. The CCl4 administration increased oxidative stress as well as the expression of transforming growth factor-b1 (TGF-b1) in the liver. Furthermore, increased a-smooth muscle actin (a-SMA) expression indicated activation of hepatic stellate cells (HSCs) and enhanced collagen production. These results indicate that both of formulations induces the resolution of liver fibrosis by decreasing oxidative stress and inactivating HSCs via down-regulation of fibrogenic cytokines, TGF-b1, more effective for silymarin/hydroxylpropyl-?-cyclodextrin.
Author(s)
Cornel, Balta
Vasile Goldis Western University of Arad, Institute of Life Sciences
Hildegard, Herman
Vasile Goldis Western University of Arad, Institute of Life Sciences
Marcel, Rosu
Vasile Goldis Western University of Arad, Institute of Life Sciences
Teodora, Mariasiu
Vasile Goldis Western University of Arad, Faculty of Medicine, Pharmacy and Dentistry
Anca, Hermenean ( presenting )
Vasile Goldis Western University of Arad, Faculty of Medicine, Pharmacy and Dentistry
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